Human Metabolomics

Metabolites can serve as a metabolic disease biomarker. In the study of biochemical reaction and signaling networks detection of such biomarkers plays a significant role. The multicomponent analysis of biological fluids, tissue and cell extracts using NMR spectroscopy and/or mass spectrometry (MS) Metabolic profiling, studies mainly involve metabolomic and metabonomic. In biological systems the measurement of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response to genetic modification and physiological, pathophysiological and/or developmental stimuli is known as Metabolic profiling (metabolomics/metabonomics).The current developments in metabolomics and metabolic profiling technologies have led to the discovery of several new metabolic biomarkers. complete and comprehensive curated collection of human metabolite and human metabolism data in the world is The Human Metabolome Database (HMDB).It contains records thousands of books, journal articles and electronic databases for more than 2180 endogenous metabolites. Metabolomic analyses like  mass spectra (MS) and Nuclear Magnetic resonance (NMR) performed on urine, blood and cerebrospinal fluid samples also contains by  HMDB In addition to its comprehensive literature-derived data. In the field of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community the HMDB is designed to address.

 

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